Online Tools

Global Distributions of M. bovis strains

• Maps representing (i) number of isolates and (ii) number of distinct profiles by country of isolation:
• Map representing the percentage of strain by country of isolation:
• Table containing more information on this distribution: here

Geographic Distribution concerning the genotyping markers

Tool displaying the distribution of a given M. bovis IT or SB number by Region of Isolation

Another tool which displays the distribution of a given IT by Country of Isolation

Distribution of the Sublineages

Tool displaying the distribution of M. bovis sublineages by Region of Isolation

Another tool which displays the distribution of M. bovis sublineages by Country of Isolation

Distribution of Hosts species

Tool displaying the distribution of M. bovis Hosts by Region of Isolation

Another tool which displays the distribution of M. bovis Hosts by Country of Isolation

Distribution of Countries in which M. bovis BCG strains were detected

Minimum Spanning Trees (MSTs) draw using BioNumerics or MLVA Compare

• MSTs (using MLVA Compare software) based on all M. bovis humain spoligotypes (PDF | PNG)
• MSTs (using BioNumerics software) based on all M. bovis isolates having 12-loci MIRU-VNTRs information (PDF | PNG)
• MSTs (using BioNumerics software) based on both spoligotyping and 12-loci MIRU-VNTRs (PDF | PNG)
• MST (using MLVA Compare software) based on 5-locus ETRs (or VNTR) versus sublineages (PNG)
• MST (using MLVA Compare software) based on 5-locus ETRs (or VNTR) versus countries of isolation (PNG)
• MST (using MLVA Compare software) based on both spoligotyping and 5-locus ETRs (or VNTR) versus sublineages (PNG)
• MST (using MLVA Compare software) based on both spoligotyping and 5-locus ETRs (or VNTR) versus countries of isolation (PNG)

Spoligoforests

Spoligoforests drawn using Fruchterman-Reingold algorithm available in SpolTools. Note that SB numbers or SIT number (abbreviated by "ST") are indicated in the trees. Colors of nodes indicate the sublineages (Download the PDF).

Note that country of isolation was unknown for 19 isolates.

Other Maps describing this database

• Map representing all countries in which M. bovis isolates were available with information on 12-loci MIRU-VNTRs (PNG)
• Map representing all countries in which wildlife was detected (n=112 isolates), and distribution of corresponding M. bovis sublineages (PNG)
• Map representing all isolates in study (n=25741), and distribution of spoligotyping based M. bovis sublineages (PNG)
• Map representing Distribution of M. bovis sublineages in Africa (PNG)
• Map representing Distribution of M. bovis sublineages in the Americas (PNG)
• Map representing Distribution of M. bovis sublineages in Asia (PNG)
• Map representing Distribution of M. bovis sublineages in Australasia (PNG)
• Map representing Distribution of M. bovis sublineages in Europe (PNG)

Note that sublineages color was assigned as follows: BOV (dark blue), BOV_1 (green), BOV_2 (red), BOV_3 (cyan blue), BOV_4-CAPRAE (yellow).

12-loci MIRULogos drawn using WebLogo web based application

• MIRULogo representing isolates belonging to BOV (or BOV_Like) sublineage (PNG)
• MIRULogo representing isolates belonging to BOV_1 sublineage (PNG)
• MIRULogo representing isolates belonging to BOV_2 sublineage (PNG)
• MIRULogo representing isolates belonging to BOV_3 sublineage (PNG)
• MIRULogo representing isolates belonging to BOV_4-CAPRAE sublineage (PNG)

Designation of loci positions 1 to 12 corresponds to classical 12-loci MIRU-VNTRs 12-loci MIRU-VNTRs: 02, 04, 10, 16, 20, 23, 24, 26, 27, 31, 39 and 40

12-loci MIRULogo stack label / number of copies for MIRU loci: A/1, B/2, C/3, D/4, E/5, F/6, G/7, H/8, I/9, J/10, K/11, L/12, M/13, N/14, O/15, P/16, Q/0, U/Unknown.